Activating transcription factor (ATF)-2, also designated CRE-BP1, is a member of the ATF/cyclic AMP-responsive element binding protein family of transcription factors. ATF2 has two unique characteristics: it mediates the adenovirus E1A-induced trans-activation and forms a heterodimer with c-Jun (1). ATF2 is a target of the JNK signal transduction pathway (2). ATF2 is phosphorylated by JNK on two closely spaced threonine residues within the NH2-terminal activation domain. The replacement of these phosphorylation sites with alanine inhibited the transcriptional activity of ATF2. Furthermore, p38 MAPK can also phosphorylate ATF2. ATF2 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, and p38 Pathway research.
序列
该【干冰】ATF2 recombinant protein-GST fusion protein - 009-001-R43S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】ATF2 recombinant protein-GST fusion protein - 009-001-R43S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】ATF2 recombinant protein-GST fusion protein - 009-001-R43S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.