Catenin α is a novel actin-binding and -bundling protein. Catenin α is responsible for organizing and tethering actin filaments at the zones of E-cadherin-mediated cell-cell contact (1). Monomeric Catenin α can bind strongly to E-Cadherin-β-Catenin, whereas the dimer preferentially binds actin filaments. Different molecular conformations are associated with these different binding states, indicating that Catenin α is an allosteric protein. Catenin α directly regulates actin-filament organization by suppressing Arp2/3-mediated actin polymerization, likely by competing with the Arp2/3 complex for binding to actin filaments (2). Catenin α Protein is ideal for investigators involved in Signaling Proteins, Transcription Proteins, Cancer, Cardiovascular Disease, Invasion/Metastasis, Neurobiology, PKA/PKC Pathway, and WNT Signaling research.
序列
该【干冰】Catenin alpha recombinant protein recombinant protein-GST fusion protein - 009-001-R57的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】Catenin alpha recombinant protein recombinant protein-GST fusion protein - 009-001-R57的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】Catenin alpha recombinant protein recombinant protein-GST fusion protein - 009-001-R57的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.