EIF2S1, also known as eukaryotic translation initiation factor 2, subunit 1 alpha, is a 35kDa protein in which The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation and promotes the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP (1). The Ser51 in the mature human EIF2-alpha protein acts as the sole site of phosphorylation that leads to repression of protein synthesis. EIF2-alpha also plays an essential role in erythropoiesis (2). EIF2S1 Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, Angiogenesis, Cellular Stress, Inflammation, Neurobiology, and Ser/Thr Kinases research.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.