PFKFB3 or 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 is a potent activator of a key regulatory enzyme in the glycolysis pathway called phosphofructokinase. Phosphofructokinase regulates the steady-state concentration of fructose-2, 6-bisphosphate, a potent activator of key regulatory enzyme of the glycolysis pathway. PFKFB3 is bifunctional, although the phosphatase activity is low due to a mutation in an active site which can be upregulated after phosphorylation by protein kinases (1). PFKFB3 may be responsible for sustaining the high glycolytic flux of rapidly proliferating leukemia cells and may represent a molecular target for chemotherapeutic intervention (2). PFKFB3 Protein is ideal for investigators involved in Signaling Proteins, Fructose Kinase Proteins, Cancer, Cell Cycle, and Metabolic Disorder research.
序列
该【干冰】PFKFB3 recombinant protein-GST fusion protein - 009-001-S88S的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】PFKFB3 recombinant protein-GST fusion protein - 009-001-S88S的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】PFKFB3 recombinant protein-GST fusion protein - 009-001-S88S的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.