中文名称

【干冰】SETD8 recombinant protein-GST fusion protein - 009-001-T28S

英文名字

【干冰】SETD8 recombinant protein-GST fusion protein - 009-001-T28S

供应商

Rockland

产品货号

009-001-T28S

产品报价

￥询价/20ug

产品说明书

购买方式

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产品新闻

背景资料

SETD8 or SET domain containing lysine methyltransferase 8 is a lysine methyltransferase that monomethylates p53 in human cell lines. The monomethylation by SETD8 suppresses p53-mediated transcriptional activation of highly responsive target genes, such as p21 (CDKN1A) and PUMA (BBC3) but it has little influence on weak p53 targets (1). Depletion of SET8 augmented the proapoptotic and checkpoint activation functions of p53, and SETD8 expression is downregulated during DNA damage. SETD8 is a Wnt signaling mediator and is recruited by LEF1/TCF4 to regulate the transcription of Wnt-activated genes, possibly through H4K20 monomethylation at the target gene promoters (2). SETD8 Protein is ideal for investigators involved in Signaling Proteins, Acetyl/Methyltransferase Proteins, Apoptosis/Autophagy, Cancer, Cell Cycle, and Neurobiology research.

序列

该【干冰】SETD8 recombinant protein-GST fusion protein - 009-001-T28S的详细信息查看Rockland提供的产品说明书。

来源宿主

该【干冰】SETD8 recombinant protein-GST fusion protein - 009-001-T28S的详细信息查看Rockland提供的产品说明书。

溶解建议

该【干冰】SETD8 recombinant protein-GST fusion protein - 009-001-T28S的详细信息查看Rockland提供的产品说明书。

保存建议

Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

其他

Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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