VRK3 is a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases which has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. Profound changes to the active site region underlie the loss of catalytic activity of VRK3 since it cannot bind ATP because of residue substitutions in the binding pocket (1). VRK3 is widely expressed in human tissues and the protein localizes to the nucleus. VRK3 regulates several transcription factors, nuclear envelope assembly, and chromatin condensation and is also required for cell cycle progression (2). VRK3 Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, JNK/SAPK Pathway, p38 Pathway, and Ser/Thr Kinases research.
序列
该【干冰】VRK3 recombinant protein-GST fusion protein - 009-001-U58的详细信息查看Rockland提供的产品说明书。
来源宿主
该【干冰】VRK3 recombinant protein-GST fusion protein - 009-001-U58的详细信息查看Rockland提供的产品说明书。
溶解建议
该【干冰】VRK3 recombinant protein-GST fusion protein - 009-001-U58的详细信息查看Rockland提供的产品说明书。
保存建议
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.