TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
应用类型
FC (QC tested)
免疫原
TRAIL-R3 (aa 1-280) - hIgGhc fusion protein
来源宿主
小鼠
反应性
Human
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.