【干冰】Anti-Kinesin-1 (Rabbit) Antibody - 100-401-E80-【干冰】Anti-Kinesin-1 (Rabbit) Antibody - 100-401-E80代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: Intracellular transport is critical to cellular functions and the maintenance of its integrity (membrane renewal, vesicles trafficking, cell division, mRNA transport, etc.). Among the molecular motors that are involved in intracellular transport, three large superfamilies have been identified and well characterized these last decades – kinesins, dyneins and myosins.nKinesins, also known as KIFs, are microtubule-dependent molecular motors that use ATP as chemical fuel to transport cargo along the microtubule network. Indeed, five major kinesin families were initially described but there are as many as 45 mammalian kinesin genes to date. In most kinesins, the motor domain is found at the N-terminus (N-type). N-type kinesins are (+) end-directed motors, i.e. they transport cargo towards the (+) end of the microtubule. In the neuronal axon, synaptic vesicle precursors, mitochondria and protein complexes are transported bi-directionally. While retrograde transport is powered by dyneins, anterograde transport is essentially powered by kinesins. nDeciphering the regulation and functions of kinesins constitutes a major challenge and will broaden our understanding of molecular motors implications in intracellular transport.

免疫原: Anti-Kinesin-1 was prepared from whole rabbit serum produced by repeated immunizations with a truncated kinesin-1 construct expressed in E. coli corresponding to human kinsesin-1 protein.

保存建议: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。