中文名称

Leptomycin B (50 ug)

英文名字

Elactocin|LMB|Mantuamycin|NSC 364372, Leptomycin B, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5S,7S,9R,11,15R,hexamethyl-8-oxo-2E,1E,12E,16Z,18E-nonadecapentaenoic acid

供应商

Cayman

产品货号

10004976-50

产品报价

￥24304/50 ug

产品说明书

购买方式

产品新闻

背景资料

Leptomycin B is a potent inhibitor of the nuclear export of proteins. It directly blocks the interaction of CRM1 -exportin 1) with nuclear export signals -NES), preventing the export of a broad range of proteins. Leptomycin B will also indirectly inhibit the export of mRNA from the nucleus by blocking the nuclear export of mRNA-binding proteins -export factors). By blocking the nuclear export of p53, leptomycin B prevents entry of human normal fibroblasts into the S phase of the cell cycle, thus inhibiting proliferation. Leptomycin B was originally identified as an antifungal agent and is isolated from Streptomyces sp..

产品描述

A potent anti-fungal antibiotic that can directly block nuclear transport by inhibiting the action of CRM1; inhibits nuclear export of HIV-1 Rev -IC50 = 0.53)

产品形式

保存建议

-20

其他

Cayman Chemical

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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