中文名称

9-Z),11-E),13-E)-Octadecatrienoic Acid methyl ester (50 mg)

英文名字

Methyl

供应商

Cayman

产品货号

10008333-50

产品报价

￥7840/50 mg

产品说明书

购买方式

产品新闻

背景资料

9Z,11E,13E-octadecatrienoic acid -.alpha.-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. .alpha.-ESA is metabolized and converted to conjugated linoleic acid -9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, .alpha.-ESA induced apoptosis through up-regulation of GADD45, p53, and PPAR.gamma.. In DLD-1 cells supplemented with .alpha.-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 uM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 uM for different isoforms of the enzymes. .alpha.-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

产品描述

.alpha.-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

产品形式

保存建议

-80

其他

Cayman Chemical

注意

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