中文名称

D-myo-Inositol-3,4,5-triphosphate -sodium salt) (5 mg)

英文名字

Ins(3,4,5)-P3|3,4,5-IP4, D-myo-Inositol-3,4,5-triphosphate -sodium salt), D-myo-inositol-3,4,5-tris(hydrogen phosphate), trisodium salt

供应商

Cayman

产品货号

10008425-5

产品报价

￥21070/5 mg

产品说明书

购买方式

产品新闻

背景资料

D-myo-Inositol-1,4,5-triphosphate -Ins-1,4,5)-P3) is a second messenger produced in cells by phospholipase C -PLC)-mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. Binding of Ins-1,4,5)-P3 to its receptor on the endoplasmic reticulum in opening of the calcium channels and an increase in intracellular calcium. D-myo-Inositol-3,4,5-triphosphate -Ins-3,4,5)-P3) is a structural analog of Ins-1,4,5)-P3 and a member of the inositol phosphate -InsP) cell signaling family of molecules. D-myo Ins-3,4,5)-P3 is 200-fold less potent than D-myo Ins-1,4,5)-P3 at initiating Ca++ release when injected into Xenopus oocytes. Ins-1,4,5)-P3 binds to Type 1, 2, and 3 subtypes of the rat recombinant IP3 receptor with Ki values of less than 25 nM, whereas Ins-3,4,5)-P3 exhibits significantly lower affinity with Ki values of 3-11 uM.

产品描述

D-myo-Inositol-3,4,5-triphosphate -Ins-3,4,5)-P3) is a structural analog of Ins-1,4,5)-P3 and a member of the inositol phosphate -InsP) cell signaling family of molecules.{8672,8344} D-myo Ins-3,4,5)-P3 is 200-fold less potent than D-myo Ins-1,4,5)-P3 at initiating Ca++ release when injected into Xenopus oocytes.{13725} Ins-1,4,5)-P3 binds to Type 1, 2, and 3 subtypes of the rat recombinant IP3 receptor with Ki values of less than 25 nM, whereas Ins-3,4,5)-P3 exhibits significantly lower affinity with Ki values of 3-11 uM.{14758}

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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