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中文名称: Anti-Human MIS

英文名字: Anti-Human MIS

供应商: ReliaTech

产品货号: 101-M572

产品报价: ￥询价/100ug

产品说明书

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产品新闻

背景资料: Müllerian inhibiting substance (MIS), also named antiMüllerian hormone (AMH), is a tissuespecific TGFβ superfamily growth factor. Its expression is restricted to the Sertoli cells of fetal and postnatal testis, and to the granulosa cells of postnatal ovary. The human MIS gene encodes a 553 amino acid residue (aa) prepropeptide containing a signal a sequence (1-24), a proregion (25-455), and the carboxylterminal bioactive protein (446-553). MIS is synthesized and secreted as a disulfidelinked homodimeric proprotein. Proteolytic cleavage is required to generate the Nterminal pro region and the C-terminal bioactive protein, which remain associated in a noncovalent complex. Recombinant C-terminal MIS has been shown to be bioactive. However, the complex with the N-terminal pro region showed enhanced activity. The Cterminal region contains the seven canonical cysteine residues found in TGF-β superfamily members. These cysteine residues are involved in interand intramolecular disulfide bonds, which forms the cysteine knot structure. Human and mouse MIS share 73% and 90% aa sequence identity in their pro region and Cterminal region, respectively. MIS induces Mullerian duct (female reproductive tract) regression during sexual differentiation in the male embryo. Posnatally, MIS has been shown to regulate gonadal functions. MIS inhibits Leydig cell proliferation and is a regulator of the initial and cyclic recruitment of ovarian follicles. MIS has also been found to have antiproliferative effects on breast, ovarian and prostate tumor cells.

应用类型: WB

免疫原: 该Anti-Human MIS的详细信息查看ReliaTech提供的产品说明书。

来源宿主: 该Anti-Human MIS的详细信息查看ReliaTech提供的产品说明书。

反应性: 该Anti-Human MIS的详细信息查看ReliaTech提供的产品说明书。

保存建议: 该Anti-Human MIS的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

其他: ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。