Cathepsin K is a member of the papain cysteine proteinase family and has been identified as the predominant proteinase responsible for the resorption of the bone matrix. The enzyme cleaves proteins such as collagen type I, collagen type II and osteonectin and therefore plays a role in bone remodeling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
序列
重组小鼠前组织蛋白酶 K蛋白产品,又称Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2.其对应NCBI基因号为1513,对应Accession号为P43235.
来源宿主
提供的【ProCTSK】重组小鼠前组织蛋白酶 K产品的来源为大肠杆菌重组表达.
溶解建议
重组小鼠前组织蛋白酶 K产品为液体即用型,其溶液组成为:2.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).