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中文名称: Anti-Mouse ALK1

英文名字: Anti-Mouse ALK1

供应商: ReliaTech

产品货号: 103-M95

产品报价: ￥询价/100ug

产品说明书

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背景资料: Transforming Growth Factor beta (TGFβ) superfamily ligands exert their biological activities via binding to heteromeric receptor complexes of two types (I and II) ofserine/threonine kinases. Type II receptors are constitutively active kinases that phosphorylate-type I receptors upon ligand binding. In turn, activated type I kinases phosphorylate downstream signaling molecules including the various smads. Transmembrane proteoglycans, including the type III receptor (betaglycan) and endoglin, can bind and present some of the TGFβ superfamily ligands to type I and II receptor complexes and enhance their cellular responses. Seven type I receptors (also termed activin receptor-like kinase (ALK)) and five type II receptors have been isolated from mammals. ALK2, 3, 4, 5, and 6 are also known as Activin R1A, BMPR1A, Activin R1B, TGFβ R1, and BMPR1B, respectively, reflecting their ligand preferences. Evidence suggests that TGFβ1, TGFβ3 and an unknown ligand present in serum can activate chimeric ALK1. ALK1 shares with other type I receptors a cysteine-rich domain with conserved cysteine spacing in the extracellular region, and a glycineand serine-rich domain (the GS domain) preceding the kinase domain. ALK1 is expressed highly in endothelial cells and other highly vascularized tissues. The expression patterns of ALK1 parallels that of endoglin. Mutations in ALK1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting a critical role for ALK 1 in the control of blood vessel development or repair. Human and mouse ALK1 share approximately 71% amino acid sequence identity in their extracellular regions.

应用类型: WB

免疫原: 该Anti-Mouse ALK1的详细信息查看ReliaTech提供的产品说明书。

来源宿主: 该Anti-Mouse ALK1的详细信息查看ReliaTech提供的产品说明书。

反应性: 该Anti-Mouse ALK1的详细信息查看ReliaTech提供的产品说明书。

保存建议: 该Anti-Mouse ALK1的详细信息查看ReliaTech提供的产品说明书。溶解建议：Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

其他: ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH)，1999年成立，总部位于德国不伦瑞克，是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外，ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品，产品线主要包括重组蛋白(细胞因子、生长因子、可溶性受体)、抗体、ELISA试剂盒等。