Clathrin is a submembrane protein that polymerizes into coat-like lattices, which results in membrane invagination. The basic oligomers are composed of three clathrin heavy chain (180 kDa) and three light chain (30 kDa) subunits and the process of polymerization is dynamically regulated by the light chains. Interaction of clathrin with the plasma membrane is mediated by adaptor proteins (AP1-4) specific for different cellular compartments. Another proteins, such as endophilin, epsin and amphiphysin are involved in membrane invagination and clathrin rearrangements. Finally, dynamin functions at the fission stage of clathrin-mediated endocytosis.
应用类型
FC (QC tested), IP, WB, ICC, ELISA
免疫原
来源宿主
小鼠
反应性
Rat, Cow, Mouse, Human, Pig
保存建议
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.