Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).{27501,27502,27504,24256} By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes.{27502} Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ‘exenatide.’ Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.{27503,27506} Exenatide also has anxiolytic and anti-depressant effects and induces satiety.{27506,27505}
产品描述
提供的艾塞那肽-4(醋酸)(1mg)产品形式为:A crystalline solid.
产品形式
Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).{27501,27502,27504,24256} By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma ��TC-1 cells, supporting efficacy in type 2 diabetes.{27502} Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ��exenatide.�� Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.{27503,27506} Exenatide also has anxiolytic and anti-depressant effects and induces satiety.{27506,27505}