Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin (Item No.15507).{25157} Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF.{25157} The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively.{25157} It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci.{25157} For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.{25158,25108}
产品描述
A natural, broad spectrum Gram-positive antibiotic that inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively); IC50 = 1.95 and 3.91 μg/ml, respectively; does not exhibit cross-resistance to antibiotic resistant bacterial strains