Prostaglandin E2 activates four distinct G protein-coupled receptors, EP1-4. Rivenprost is a potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively).{10581} It has been used to promote EP4-mediated bone formation, prevent bone loss related to osteoporosis, drive osteoblast differentiation, and stabilize bone implants.{10581,18823,18825,18824,18827} Rivenprost has also been used to support wound healing.{18826}
产品描述
A potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively); promotes EP4-mediated bone formation, prevention of bone loss related to osteoporosis, osteoblast differentiation, and the stabilization of bone implants; supports wound healing