中文名称

5-溴-7- [5-脱氧-5-[[3-[[[[4-（1,1-二甲基乙基）苯基]氨基]羰基]] [氨基]丙基] [（1-甲基乙基）氨基]-β-D-呋喃呋喃糖基] -7H-吡咯并[2,3-d]嘧啶-4-胺

英文名字

5-​bromo-​7-​[5-​deoxy-​5-​[[3-​[[[[4-​(1,​1-​dimethylethyl)​phenyl]​amino]​carbonyl]​amino]​propyl]​(1-​methylethyl)​amino]-​β-​D-​ribofuranosyl]-7H-pyrrolo[2,​3-​d]​pyrimidin-​4-​amine

供应商

Cayman Chemical

产品货号

13967-5

产品报价

￥询价/5mg

产品说明书

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购买方式

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产品新闻

背景资料

Dot1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-, di-, and trimethylation.{21195} Proper Dot1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation.{21198} SGC0946 is a potent inhibitor of DOT1L (IC50 = 0.3 nM) developed by Structural Genomics Consortium laboratories (probes/SGC0946">(www.thesgc.org/chemical-probes/SGC0946)). It is over 100-fold selective over other PMTs. It is active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively). SGC0946 is a brominated analog of EPZ004777, an S-adenosylmethionine-competitive inhibitor of DOT1L.{27033} Both SGC0946 and EPZ004777 selectively kill mixed lineage leukemia (MLL) cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein.{27033}

产品描述

A potent inhibitor of DOT1L (IC50 = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively)

产品形式

A crystalline solid

保存建议

建议您在收到Cayman Chemical品牌的SGC0946 (5 mg)产品后置于-20度保存，产品有效期为730天.

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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