15-keto Latanoprost is a potential metabolite of Latanoprost when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound Latanoprost, 15-keto Latanoprost still retains the ability to produce a small but measurable decrease -1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 ug/eye. 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 ug/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2.alpha. will produce this degree of miosis at a dose of less than 1 ug/eye.
产品描述
A potential metabolite of latanoprost when administered to animals; common minor impurity found in commercial preparations of the bulk drug compound