中文名称

YM-53601 (10 mg)

英文名字

YM-53601, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride

供应商

Cayman

产品货号

18113-10

产品报价

￥32928/10 mg

产品说明书

购买方式

产品新闻

背景资料

Squalene synthase catalyzes the dimerization of two farnesyl pyrophosphate molecules to form the key cholesterol precursor, squalene.,YM-53601 inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells with IC50 values of 90 and 79 nM, respectively. Cholesterol biosynthesis is inhibited in rats with an ED50 value of 32 mg/kg YM-53601, causing a reduction in both cholesterol and triglyceride levels in plasma. Cholesterol-reducing HMG-CoA reductase inhibitors, which have little effect on plasma triglyceride levels, are often paired with fibrates, which can have adverse effects, to treat hyperlipidemia. The lipid-lowering properties of compounds such as YM-53601 make squalene synthase inhibition an attractive alternative to the combination HMG-CoA reductase inhibitor/fibrate therapy.,

产品描述

Inhibits squalene synthase activity in rat hepatic microsomes and human Hep-G2 cells (IC50 values of 90 and 79 nM, respectively); inhibits cholesterol biosynthesis in rats reducing both cholesterol and triglyceride levels in plasma

产品形式

保存建议

-20

其他

Cayman Chemical

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：