中文名称

HLI 373（盐酸盐）

英文名字

HLI 373 (hydrochloride)

供应商

开曼生物

产品货号

18221-1

产品报价

￥1/50mg

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产品新闻

背景资料

Hdm-2 (human double minute-2; Mdm-2 in mouse) is a ubiquitin ligase and key negative regulator of p53, targeting it for proteasomal degradation. Overexpression of Hdm-2 in some tumors leads to inactivation of p53, thereby allowing tumor cells to escape p53-induced apoptosis.{13684} HLI 373 is an inhibitor of Hdm-2.{29613} At concentrations of 5-50 ?M, it selectively inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53.{29613} Through these actions, HLI 373 stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and mouse embryo fibroblasts harboring wild-type p53.{29613}

产品描述

An inhibitor of Hdm-2 that inhibits autoubiquitylation of Hdm-2 as well as the ubiquitylation and degradation of p53; stabilizes p53 and increases p53-dependent transcription, inducing apoptosis of transformed cells, tumor cells, and MEFs harboring wild-type p53

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