中文名称

人纤维蛋白原 (PAD2环)（1mg）

英文名字

Human Fibrinogen (PAD2 Citrullinated)

供应商

Cayman Chemical

产品货号

18473-1

产品报价

￥询价/1mg

产品说明书

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购买方式

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产品新闻

背景资料

Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and r). Under chronic inflammatory conditions, fibrinogen can be acted upon by the peptidylarginine deiminases enzymes (PAD2 and PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.{21644} The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.{21645,21643} Immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.{21646,21647}

产品描述

Source:Purified from human plasma, citrullinated with human recombinant PAD2 • MW: α chain isoform 1 (95 kDa), α chain isoform 2 (69.8 kDa), β chain (55.9k Da), and,isoform r-B chain (51.5 kDa)

产品形式

Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (��, �� and r). Under chronic inflammatory conditions, fibrinogen can be acted upon by the peptidylarginine deiminases enzymes (PAD2 and PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.{21644} The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.{21645,21643} Immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.{21646,21647}

保存建议

建议收到产品后-80℃保存，避免反复冻融

其他

Cayman Chemical向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.Cayman Chemical可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为Cayman Chemical在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Cayman Chemical产品以及客户订制化服务.

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

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