Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball (1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al. (1989) localized the gene to 2q35. Desmin mutation responsible for idiopathic dilated cardiomyopathy. This antibody is suitable for researchers interested in cancer research, cardiovascular diseases, neurodegenerative diseases, cell adhesion research, and cytoskeletal signaling research.
应用类型
ELISA,Immunohistochemistry,Western Blot,
免疫原
Desmin antibody was produced in mice by repeated immunizations with desmin from pig stomach.
来源宿主
Mouse
反应性
H. sapiens (Human); Leporidae (Rabbit); Mus musculus (Mouse); Rattus (Rat)
保存建议
Store vial at 4° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.