【干冰】Anti-Apoptosis Inducing Factor (AIF) (RABBIT) Antibody - 200-401-985-【干冰】Anti-Apoptosis Inducing Factor (AIF) (RABBIT) Antibody - 200-401-985代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: 【干冰】Anti-Apoptosis Inducing Factor (AIF) (RABBIT) Antibody - 200-401-985

英文名字: 【干冰】Anti-Apoptosis Inducing Factor (AIF) (RABBIT) Antibody - 200-401-985

背景资料: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of the caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like cytochrome c and caspase-9, which are critical molecules in apoptosis, AIF localizes to mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis. These effects occur in both isolated nuclei and in the nuclei of live cells treated by microinjection and with apoptosis stimuli. AIF is highly conserved between human and mouse and is widely expressed. Anti-AIF antibody is ideal for investigators involved in DNA Damage and Repair and Chromatin research.

免疫原: AIF Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids at an internal region of human AIF protein.

保存建议: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。