【干冰】Anti-GAB1 (RABBIT) Antibody - 200-401-G66S-【干冰】Anti-GAB1 (RABBIT) Antibody - 200-401-G66S代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

开云·官方站线上登录平台入口_开云(中国)

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背景资料: GAB1 antibody detects GAB1 which is a member of the IRS1-like multisubstrate docking protein family. The protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. GAB1 plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. It is known to play a role in FGFR1 signaling and is probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). GAB1 interacts with GRB2 and with other SH2-containing proteins. It is known to interact with phosphorylated LAT2, PTPRJ, FRS2, GRB2, PIK3R1 and SOS1. GAB1 gets phosphorylated in response to FGFR1 activation. This tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Anti-GAB1 Antibody is ideal for investigators involved in Cell Signaling, Cancer, Neuroscience and Signal Transduction research.

免疫原: Anti-GAB1 Antibody was produced in rabbits by repeated immunizations with a recombinant protein produced in Sf9 cells corresponding to the full length human GAB protein.

保存建议: Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 µL). To minimize loss of volume dilute 1:10 by adding 225 µL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

其他: Rockland成立于1962年，是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物。Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。