CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It is a member of the immunoglobulin superfamily. On T cells, it is the co-receptor for the T cell receptor (TCR) and amplifies the signal generated by the TCR by recruiting the tyrosine kinase lck that is essential for activating many molecules involved in the signaling cascade of an activated T cell. It is an important component of the immune system and is also the cellular receptor for HIV-1. It consists of a cytoplasmic tail, one transmembrane region, and four extracellular domains, D1-D4. It maps to 12pter-p12 region of human chromosome.
应用类型
Flow Cytometry,IF Microscopy,
免疫原
Anti-CD4 Antibody (Monoclonal) was produced by repeated immunizations with Mouse CTL clone V4.
来源宿主
Rat
反应性
Mus musculus (Mouse)
保存建议
Store vial at 4° C prior to opening. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. DO NOT FREEZE. This product is light sensitive.