中文名称

Leukotriene B4 Ethanolamide (500 ug)

英文名字

LTB4-EA, Leukotriene B4 Ethanolamide, N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,1E,14Z-eicosatetraenamide

供应商

Cayman

产品货号

20112-500

产品报价

￥25088/500 ug

产品说明书

购买方式

产品新闻

背景资料

The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM. LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.

产品描述

A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM)

产品形式

保存建议

-20

其他

Cayman Chemical

注意

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