A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor g (RORg) and acts as a highly selective and inverse agonist (Ki =105nM; IC50 ~320nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.Formula:C26H24F7N3OMolecular Weight:527.5Solubility:DMSO (50mg/ml)Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
产品形式
该产品为白色粉末。
保存建议
接收到RORg Inverse Agonist, SR2211 (1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4'-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211)产品后,置于-20°C温度下保存。