TACE抗体-TACE Antibody，TACE，CD156b，Disintegrin and metalloproteinase domain-containing protein 17； ADAM 17； TNF-alpha-converting enzyme； TNF-alpha convertase； Snake venom-like protease代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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二抗

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英文名字: TACE Antibody，TACE，CD156b，Disintegrin and metalloproteinase domain-containing protein 17； ADAM 17； TNF-alpha-converting enzyme； TNF-alpha convertase； Snake venom-like protease

背景资料: Tumor necrosis factor- （TNF-） is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF- is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-. TNF- converting enzyme （TACE） protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately. TACE is a membrane-bond metalloprotease-disintegrin in the family of mammalian ADAM （for a disintegrin and metalloprotease）. TACE also processes other cell surface proteins，including TNF receptor，TGF-，L-selectin adhesion molecule，and alpha-cleavage of amyloid protein precursor （APP）. TACE mRNA is expressed in a variety of human and murine tissues.

应用类型: Western blotting （1-2 ug/ml）. However， the optimal conditions should be determined individually. The immunoaffinity purified antibody detects 80-130 kDa bands， which may represent mature protein， precursor and glycosylated TACE. HeLa and Jurkat cell lysate can be used as positive control.

保存建议: 提供的TACE抗体产品为100 ug 无色溶液，其浓度为0.5 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）缓冲液中.请将该TACE抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.

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