FKBP38 Antibody,FKBPR38,FKBP8,FKBP 8,FK506 binding protein 8 ,FKBP 38
供应商
Biovision
产品货号
3666-100
产品报价
¥已停产
产品说明书
购买方式
银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868.
产品新闻
背景资料
FK506-binding protein 38 (FKBP38),a member of the immunophilin family,has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion,resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
应用类型
Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide (Cat.# 3666BP-50) is available separately. The antibody recognizes a ~40 kDa band in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 344 of mouse FKBP38
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的FKBP38蛋白发生免疫反应.
保存建议
提供的FKBP38抗体产品为100 ug 无色溶液,其浓度为0.2 mg/ml,溶解于包含有0.1% BSA, 20%甘油和0.02%硫柳汞的PBS缓冲液中.请将该FKBP38抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.