JNK Antibody,JNK1,JNK 1,JNK1 antibody ,SARP,JNK1A2,JNK,JAK 1A,JAK1A,Stress activated protein kinase
供应商
Biovision
产品货号
3701-100
产品报价
¥已停产
产品说明书
购买方式
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产品新闻
背景资料
The JNK pathway is activated by largely distinct stimuli including inflammatory cytokines (such as TNF- and IL-1),UV light,inhibitors of protein synthesis and osmotic stress. Activated MEKK1 phosphorylates SEK1 (also known as MKK4),which in turn activates SAPK (also known as JNK). JNK binds tightly to the N-terminal region of c-Jun and ATF-2,and phosphorylates c-Jun at Ser63 and Ser73 and ATF-2 at Thr69 and Thr71.
应用类型
Western blotting (0.5-4 ug/ml),immunoprecipitation (10-20 ug/ml), and Immunohistochemistry (10-20 ug/ml). Reacts with human and to a lesser extent with mouse and rat. However, the optimal conditions should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 412 of human JNK-1
来源宿主
兔
反应性
经检测验证,可与人、小鼠、大鼠种属来源的JNK蛋白发生免疫反应.
保存建议
提供的JNK抗体产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有30%甘油, 0.5% BSA, 0.01%硫柳汞的PBS (pH 7.2)缓冲液中.请将该JNK抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.