IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.
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重组小鼠干扰素-γ蛋白产品,又称Immune Interferon-γ, type II interferon, T cell interferon, MAF.其对应NCBI基因号为3458,NCBI基因别称为IFNG;该基因种属来源为人源,对应Accession号为P01579.该蛋白产品又称Murine IFN-γ, IFN-γ, IFNγ, IFN γ, m- IFN-γ, rm- IFN-γ, recombinant murine IFN-γ, recombinant IFN-γ, IFN等.