IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
序列
重组小鼠白介素-4蛋白产品,又称BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra,.其对应NCBI基因号为16189,NCBI基因别称为IL4;该基因种属来源为小鼠源,对应Accession号为P07750 .该蛋白产品又称Murine IL-4, IL-4, IL4, IL 4, m-IL-4, rm-IL-4, recombinant murine IL-4, recombinant IL-4, IL, interluekin等.