IL-12 is a potent regulator of cell mediated immune responses and in induces IFN- production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN- producing Th1 cells. Recombinant human IL-12 is a 75 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (503 total amino acid residues).
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重组人白介素-12蛋白产品,又称NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-α, IL-12 .其对应NCBI基因号为332,NCBI基因别称为BIRC5;该基因种属来源为人源,对应Accession号为O15392.该蛋白产品又称Human IL-12, IL-12, IL12, IL 12, h-IL-12, rh-IL-12, recombinant human IL-12, recombinant IL-12, IL, interluekin等.