Advanced glycosylation end product-specific receptor, also known as receptor for advanced glycosylation end products, AGER and RAGE, belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serves as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
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重组人晚期糖基化终产物受体蛋白产品,又称Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER.其对应NCBI基因号为117,对应Accession号为Q15109.
来源宿主
提供的【RAGE】重组人晚期糖基化终产物受体产品的来源为人细胞重组表达.
溶解建议
重组人晚期糖基化终产物受体产品请按照说明书建议进行溶解操作:Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). After adding 1x PBS, let the tube stand at room temperature for 3 minutes to allow lyophilized protein to dissolve. Mix the solution by inverting the tube 5 times. Centrifuge to pool sample.