Human Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family. CCL23 is also known as myeloid progenitor inhibitory factor MPIF-1, CK8 and SCYA23. CCL23 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CCL23 (aa 22 -120).Additional N-terminal Processing of the 99 aa residue
variant can generate a 75 aa residue peptide (aa 46-120) that is significantly more active than the 99 aa residue variant. CCL23 binds to CCR1 with high affinity and has chemotactic activity for monocytes, dendritic cells, and osteoclast precursors. CCL23 enhances angiogenesis of endothelial cells, but reduces the proliferation of progenitor cells giving rise to granulocyte and monocyte lineages.
重组人趋化因子CCL23/Ck β 8-1产品请按照说明书建议进行溶解操作:Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 ug/ml.). This can further be diluted to other aqueous buffers.