RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant human RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
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重组人正常T细胞表达和分泌因子蛋白产品,又称Small inducible cytokine A5, CCL5, T-cell-specific RANTES protein, SIS-delta, T cell- specific protein P228, TCP228, chemokine (C-C motif) ligand 5, SISd, SCYA5, RANTES, D17S136E, MGC17164. .其对应NCBI基因号为8600,NCBI基因别称为OPGL;该基因种属来源为人源,对应Accession号为O14788 .该蛋白产品又称Human RANTES, RANTES, h-RANTES, rh-RANTES, recombinant human RANTES, recombinant RANTES等.