Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli.
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重组人格里莫林-2蛋白产品,又称Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, Protein related to DAN and cerberus, DAN domain family member 3.其对应NCBI基因号为64388,NCBI基因别称为GREM2;该基因种属来源为人源,对应Accession号为Q9H772.该蛋白产品又称Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, Protein related to DAN and cerberus, DAN domain family member 3等.