ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. It’s interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues (Accession No. AAB59397). This protein has a N-terminal His-tag.
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重组人载脂蛋白E4蛋白产品,又称Apolipoprotein E4, APOE, apolipoprotein, apolipoproteins.其对应NCBI基因号为348,NCBI基因别称为APOE;该基因种属来源为人源,对应Accession号为NM_000041.该蛋白产品又称Human ApoE4, ApoE4, Apo-E4, Apo E4, h-ApoE4, rh-ApoE4, recombinant human ApoE4, recombinant human ApoE4, Apo等.