CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and Vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF β1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.
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重组人结缔组织生长因子蛋白产品,又称Connective Tissue Growth Factor, CCN2, Hypertrophic chondrocyte-specific protein 24 (HCS24), Insulin-like growth factor-binding protein 8.其对应NCBI基因号为1490,NCBI基因别称为CTGF;该基因种属来源为人源,对应Accession号为NM_001901.该蛋白产品又称Human CTGF, CTGF, h-CTGF, rh-CTGF, recombinant human CTGF, recombinant human CTGF, CTGF等.