Human IGF-BP3, also known as growth-hormone-dependant binding protein, is a 28.9 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals. In addition to its ability to modulate the activity of IGF-I and IGF-2, IGF-BP3 also exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
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重组人胰岛素样生长因子结合蛋白-3蛋白产品,又称Insulin-like Growth Factor-Binding Protein 3, Growth-hormone-dependant binding protein.其对应NCBI基因号为3484,NCBI基因别称为IBP1;该基因种属来源为人源,对应Accession号为P08833.该蛋白产品又称Human IGF-BP3, IGF-BP3, IGFBP3, h-IGF-BP3, rh-IGF-BP3, recombinant human IGF-BP1, recombinant IGF-BP1, IGF等.