Human CellExp Progranulin (untagged), Rat Recombinant
供应商
Biovision
产品货号
4736-50
产品报价
¥已停产
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产品新闻
背景资料
Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
序列
人源细胞表达的重组大鼠颗粒蛋白前体 (无标签)蛋白产品,又称Proepithelin, PEPI, PC Cell-derived Growth Factor.其对应NCBI基因号为10116,对应Accession号为P23785.