The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma. Recombinant human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.
序列
重组人三叶因子2蛋白产品,又称Trefoil Factor 2, Spasmolytic polypeptide (SP), Spasmolysin.其对应NCBI基因号为7032,NCBI基因别称为TFF2;该基因种属来源为人源,对应Accession号为Q03404.该蛋白产品又称SP, SML1, TFF2, Trefoil Factor 2, Trefoil Factor peptide, pS2 protein, HP1.A, Breast Cancer Estrogen-Inducible protein (BCEI), PNR2等.