CD14 acts as a receptor for endotoxin (LPS), is expressed strongly on monocy¬tes, macro¬pha¬ges and weekly at surface of neutrophiles. CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high affinity receptor LPS-LBP (lipopolysaccharide binding protein)-complexes. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids, acts at physiological concentrations as LPS agonist and has at higher concentrations an antagonizing effect in cell activation. The myeloid differentiation antigen CD14 acts as the major receptor for bacterial LPS. The dominant form of the recombinant wild type CD14 is the 50 kDa protein.
序列
重组人CD-14蛋白产品,又称CD14, Cluster of differentiation 14, Human CD14, CD14, h-CD14, rh-CD14, recombinant human CD14, recombinant CD14, CD14, Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein.其对应NCBI基因号为929,对应Accession号为P08571.
来源宿主
提供的【CD 14】重组人CD-14产品的来源为中国仓鼠卵巢CHO细胞重组表达.
溶解建议
重组人CD-14产品请按照说明书建议进行溶解操作:Reconstitute in 10 ul of ultra-pure distilled water. This solution can then be diluted into other aqueous buffers and stored at –20°C or –70°C for future use. .