ATG3 Antibody (Center) (Autophagy related protein 3, APG3, APG3-like, PC3-96)
供应商
Biovision
产品货号
5061-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation,an essential step for the initiation of autophagy. It functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate,which is critical for autophagy.
应用类型
Western Blot: 1 - 2 ug/ml, Immunohistochemistry, ELISA. However, the optimal conditions should be determined individually.
免疫原
ATG3 antibody was raised against an 18 amino acid peptide near the center of human ATG3.