TAB3 Antibody (NT) (MAP3K7-interacting protein 3, MAP3K7IP3, NAP1)
供应商
Biovision
产品货号
5084-100
产品报价
¥已停产
产品说明书
购买方式
银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868.
产品新闻
背景资料
TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2,form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy,these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy,while their depletion triggers it,suggesting that TAB2 and TAB3 act as a control point for autophagy.
应用类型
Immunohistochemistry: 5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
TAB3 antibody was raised against a 13 amino acid peptide near the amino terminus of human TAB3.