SHANK3 Antibody (Center) (SH3 and multiple ankyrin repeat domains 3, ProSAP2, PSAP2, SPANK-2, Proline-rich synapse-associated protein 2)
供应商
Biovision
产品货号
5317-100
产品报价
¥已停产
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产品新闻
背景资料
SH3 and multiple ankyrin repeat domains 3 (SHANK3),a member of the Shank gene family,plays a role in synapse formation and dendritic spine maturation. Shank proteins (Shank 1-3) containing PDZ domains are scaffold proteins of the postsynaptic density (PSD) that connect neurotransmitter receptors and ion channels proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development. Mutations of SHANK3 are a cause of autism spectrum disorder (ASD) and the neurological symptoms of 22q13.3 deletion syndrome.
应用类型
Western Blot: 1 ug/ml, IHC: 2.5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
SHANK3 antibody was raised against a 19 amino acid synthetic peptide near the center of human SHANK3.