WDR35 Antibody (NT) (WD repeat-containing protein 35, CED2)
供应商
Biovision
产品货号
5403-100
产品报价
¥已停产
产品说明书
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产品新闻
背景资料
WD40 repeats are a common structural module in eukaryotic proteins,and proteins containing WD40 domains have a wide range of functions,including signal transduction,cell cycle regulation,RNA splicing,and transcription. One such protein,WDR35,also known as CED2,has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED),an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.
应用类型
IHC: 5 ug/ml, ELISA. However, the optimal conditions should be determined individually.
免疫原
WDR35 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human WDR35.