骨桥蛋白（N末端）（克隆号2C5）-Anti-Osteopontin （NT）（Clone 2C5）（OPN， BNSP， Bone sialoprotein 1， Nephropontin， Secreted phosphoprotein 1， SPP-1， Urinary stone protein， Uropontin.）代理/参数/厂家-二抗-开云·官方站线上登录平台入口

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中文名称: 骨桥蛋白（N末端）（克隆号2C5）

英文名字: Anti-Osteopontin （NT）（Clone 2C5）（OPN， BNSP， Bone sialoprotein 1， Nephropontin， Secreted phosphoprotein 1， SPP-1， Urinary stone protein， Uropontin.）

供应商: Biovision

产品货号: 5422-100

产品报价: ￥已停产

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背景资料: Human Osteopontin （OPN） is a negatively charged hydrophilic protein of 314 amino acids and is subject to significant post translational modifications （PTM） including phosphorylation and glycosylation. Due to its acidic nature and PTMs，OPN runs anomalously by SDS-PAGE. Although its mass is 35kD，apparent molecular weights may range up to 75kD. In addition，OPN is subject to proteolytic modification into smaller molecular weight fragments. The matricellular protein osteopontin binds to cell surface receptors and is secreted into many body fluids including milk，blood and urine，depending on the organ of origin. This makes osteopontin an ideal candidate for being a biomarker as the secreted form is easily obtained in throwaway fluids，and mimics the cellular environment from which it is released. Osteopontin is important in immune responses and inflammation as well as bone generation and remodeling. In autistic children，serum levels of osteopontin are correlated to the severity of disease，probably due to a brain inflammation pattern in these children. In aortic valve sclerosis and stenosis，increased levels of secreted osteopontin are also noted. Osteopontin has also been suggested as a cancer biomarker，since it is associated with tumor formation，progression and metastasis. In bone and tooth formation osteopontin is known to be a negative regulator of parathyroid hormone-related protein receptor，which induces osteogenesis. Without appropriate levels of osteopontin，bone growth continues unregulated，and leads to specific bone cancers. In short，osteopontin is a strong marker for bone growth，inflammation and certain cancers. The newly exposed SVVYG epitope on the N-terminal fragment has also been shown to participate in cell adhesion.

应用类型: ELISA - Sandwich and Indirect

免疫原: Recombinant full-length human Osteopontin

来源宿主: 小鼠

反应性: 经检测验证，可与人（奶源中的天然OPN蛋白）种属来源的Osteopontin （N末端）（克隆号2C5）蛋白发生免疫反应.

保存建议: 提供的Osteopontin （N末端）（克隆号2C5）产品为无色溶液形式，含有100 ug抗体.该产品浓度为1 mg/ml，溶解于0.15 M PBS缓冲液中.请在收到该Osteopontin （N末端）（克隆号2C5）产品后，将其置于-20 °C冷冻保存，建议分装使用以避免反复冻融.

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